Identification of hemagglutinin and neuraminidase genes of influenza B virus

Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape.

The cytoplasmic tails of the influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA) are highly conserved in sequence for all virus subtypes and it is believed that assembly of this enveloped virus depends on interactions of these domains with cytoplasmic viral components. However, it is possible to rescue altered influenza viruses lacking either the HA or NA cytoplasmic tails. ...

Genome Stability of Pandemic Influenza A (H1N1) 2009 Based on Analysis of Hemagglutinin and Neuraminidase Genes

Influenza A virus (H1N1), which arose in 2009, constituted the fourth pandemic after the cases of 1918, 1957, and 1968. This new variant was formed by a triple reassortment, with genomic segments from swine, avian, and human influenza origins. The objective of this study was to analyze sequences of hemagglutinin (n=2038) and neuraminidase (n=1273) genes, in order to assess the extent of diversi...

Replication of influenza B virus: biological functions of viral neuraminidase.

My virus research started at the Department of Bacteriology, Nagoya Univt'rsity School of Medicine as a postgraduate student in 1959. Initially, I took part in a series of D:. Matsumoto's studies on host-controlled variation of paramyxovirus. 1) These studies provided me with the background necessary for virus research. After this work, I began to study persistent infection of cell culture by p...

Isolation and Identification of Avian Influenza Virus H9N2 Subtype

Label‐free mass spectrometry‐based quantification of hemagglutinin and neuraminidase in influenza virus preparations and vaccines

BACKGROUND Influenza vaccination is the primary method for preventing influenza and its severe complications. An accurate rapid method to determine hemagglutinin (HA) concentration would facilitate reference antigen preparation and consequently expedite availability of seasonal as well as pandemic vaccines. OBJECTIVE The goal of this study was to develop a label-free mass spectrometry (MS) ba...